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KMID : 0360220080490122017
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Journal of the Korean Ophthalmological Society
2008 Volume.49 No. 12 p.2017 ~ p.2020
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Central Retinal Artery Obstruction in Protein S Deficiency
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Lee Sung-Bok
Kim Jung-Yeul
Yun Young-Jun
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Abstract
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Purpose: To report a case of central retinal artery obstruction (CRAO) caused by protein S deficiency.
Case summary: A 36-year-old man presented with acutely reduced visual acuity in the right eye. The patient had no other diseases such as diabetes mellitus or hypertension. The visual acuity was 20/20 in the right eye and light perception in the left eye. Afferent pupillary defect was observed in theleft eye. Fundus examination showed diffuse retinal opacification and a cherry-red spot at the macula. Thus the patient was diagnosed with CRAO in the left eye. There were no abnormal findings on routine hematologic tests including blood coagulation test. Protein C activity, antithrombin III activation, anticardiolipin antibody were within normal limits but protein S activity was decreased. Thus, the patient was diagnosed with CRAO with protein S deficiency.
Conclusions: Coagulation factors such as protein S need to be measuredin cases of CRAO in young patients without medical problems.
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KEYWORD
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Central retinal artery obstruction, Hypercoagulable state, Protein S
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